Dextropropoxyphene, additionally known as propoxyphene and propoxyphene hydrochloride, is a medicine that’s prescribed to deal with ache. Dextropropoxyphene overdose signs generally happen when somebody takes an excessive amount of of the remedy or combines it with one other substance, akin to alcohol.

Dextropropoxyphene is an in depth relative of the drug methadone. It was first marketed in 1957 underneath the model identify Darvon. Its oral analgesic energy is about one-half to one-third that of codeine. Whereas dextropropoxyphene is prescribed for reduction of delicate to average ache, massive quantities of this drug are labeled as a Schedule II managed substance. The U.S. Drug Enforcement administration reviews that greater than 100 tons of dextropropoxyphene are produced yearly in the USA, and over 30 million prescriptions are written every year for merchandise containing this narcotic. Dextropropoxyphene can also be offered beneath the model names Darvocet, Darvon-N and Dolene.


Dextropropoxyphene merchandise taken in massive doses, both alone or with alcohol or different central nervous system depressants, are a number one explanation for drug-related deaths. That is largely as a result of the mixed impact of the substances is bigger than the consequences of every substance individually.

People who find themselves addicted to a different substance, similar to alcohol, face an elevated danger of experiencing doubtlessly life-threatening overdose signs in the event that they take an excessive amount of dextropropoxyphene. That is true of many medication, whether or not they’re taken illicitly or with a prescription.


In line with the College of Maryland Medical Middle, indicators of an overdose on dextropropoxyphene can fluctuate. An overdose could have an effect on a number of programs in your physique, together with the respiratory and circulatory signs. The severity of dextropropoxyphene overdose signs will differ relying on a number of parts, corresponding to the quantity of medicine you’ve ingested, and whether or not you’ve taken different substances equivalent to alcohol or chilly medicines as properly. Generally, dextropropoxyphene overdose signs will embrace a number of the next:

  • Blue fingernails or lips
  • Pores and skin rash
  • Nausea
  • Vomiting
  • Stomach cramps
  • Listening to loss
  • Constricted pupils
  • Disturbances in coronary heart rhythm
  • Low blood strain
  • Weak pulse
  • Problem respiratory
  • Slowed, labored or shallow respiratory
  • Stopped respiratory perform
  • Muscle spasticity
  • Drowsiness
  • Seizures
  • Coma

In case you are experiencing dextropropoxyphene overdose signs, otherwise you suspect that somebody has overdosed on this treatment, it’s important that you just get medical consideration instantly.


Whenever you name emergency providers for another person, chances are you’ll be requested questions relating to the affected person and his or her scenario. If you’re in search of dextropropoxyphene overdose therapy for your self, medical personnel on the hospital could ask these questions if you arrive, so long as you’re acutely aware and capable of reply coherently. This info will be sure that medical personnel can present one of the best overdose therapy potential, and this improves the chances of restoration from overdose. This data normally contains:

  • Affected person’s age, weight, and signs
  • The model identify of the drug taken, and its power
  • The time of the final dose
  • The quantity of drug ingested
  • If the remedy was prescribed for the affected person
  • Any substances taken with the treatment

On the emergency room, medical personnel will assess and monitor your temperature, blood strain, pulse and respiratory situation. Critical signs, together with respiration perform points, coronary heart disturbances, and neurological points will likely be handled instantly by correct dextropropoxyphene detox and withdrawal therapy. Dextropropoxyphene overdose remedy may additionally embody the next strategies of remedy:

  • Activated charcoal
  • Intravenous fluids
  • Drugs to dam the impact of dextropropoxyphene on the central nervous system
  • Gastric lavage to scrub out the contents of the abdomen